Product ID:BUPIVACAINE HYDROCHLORIDE INJ.,USP
MSDS Date:12/13/1991
FSC:6505
NIIN:00-149-3500
MSDS Number: BWMPK

Emergency Phone: 708-937-7970/800-323-9100

Info Phone: 708-937-7970/800-323-9100

Cage: 0ALT7

Telephone: 847-935-7177

Cage: 60060

BUPIVACAINE HYDROCHLORIDE

CAS: 18910-40-7

AQUEOUS SOLUTION

LD50 LC50 Mixture:LD50 (SCU, RAT) IS 48 MG/KG.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:CONTAINS BUPIVACAINE HYDROCHLORIDE IN
AQU SOLN.HEALTH RELATED DATA FOR PROD BASED ON BUPIVACAINE
HYDROCHLORIDE CONTENT.LOC ANESTHETIC THAT PRODUCES ANESTHESIA
(NUMBUNESS) BY BLOCKAGE OF NERVE CONDUCTI ON & ADVERSELY AFFECT CNS
& HEART.
Explanation of Carcinogenicity:PER
MSDS:CARCINOGENICITY:NTP/IARC/OSHA/ACGIH:NOT LISTED.
Effects of Overexposure:NONE FROM INTACT VIALS. IN CLINICAL USE EFFECTS
INCLUDE NUMBNES, DIZZ, RESTLESSNESS, EXCITATION/DEPRESS, ANXIETY,
TINNITIS, BLURRED VISION, TREMORS, CONVULSIONS, HYPOTENSION,
BRADYCARDIA, VENTRICULAR ARRHYTHMIAS, HEART BLOCK, AND CARDIAC
ARREST.
Medical Cond Aggravated by Exposure:DATA SUGGEST PRE-EXISTING CENTRAL
NERVOUS SYSTEM OR CARDIOVASCULAR AILMENTS. HYPERSENSITIVITY TO
AMIDE-TYPE LOCAL ANESTHETICS.

First Aid:REMOVE FROM SOURCE OF EXPOSURE. SKIN/EYE CONTACT OCCURS FLUSH
W/COPIOUS AMTS OF WATER. IF IRRIT PERSISTS OR SIGNS OF TOXICITY
OCCUR SEEK MED ATTN. NO KNOWN ANTIDOTE. PROVIDE
SYMPTOMATIC/SUPPORTIVE CAR E, MAINTAINING VENTILATION,
CONTROLLINGCONVULSIONS, AND MONITORING CARDIOVASCULAR FUNCTION, AS
NECESSARY.

Flash Point:NON-FLAMMABLE
Extinguishing Media:PER MSDS:N/A. HOWEVER USE APPROPRIATE EXTINGUISHING
MEDIA FOR SURROUNDING FIRE.
Fire Fighting Procedures:NONE.
Unusual Fire/Explosion Hazard:NONE.

Spill Release Procedures:CLEAN UP PROMPTLY, AVOID SKIN/EYE CONTACT.
Neutralizing Agent:NONE SPECIFIED BY MFG.

Handling and Storage Precautions:NONE.
Other Precautions:NONE.

Respiratory Protection:NONE REQUIRED.
Ventilation:NO SPECIAL PROVISIONS REQUIRED.
Protective Gloves:NONE REQUIRED.
Eye Protection:NONE REQUIRED.
Work Hygienic Practices:WASH HANDS AFTER HANDLING.
Supplemental Safety and Health

HCC:N1
Boiling Pt:B.P. Text:WATER(APRX)
Melt/Freeze Pt:M.P/F.P Text:WATER(APRX)
Spec Gravity:WATER(APPROX)
pH:4.-6.5
Viscosity:WATER(APPROX)
Solubility in Water:AQUEOUS SOLUTION
Appearance and Odor:CLEAR LIQUID.
Percent Volatiles by Volume:NELGIG

NONE.
Stability Condition to Avoid:NONE.
Hazardous Decomposition Products:NONE.

Waste Disposal Methods:NO SPECIAL REQUIREMENTS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.